Methamphetamine

National Institute on Drug Use (www.drugabuse.gov)

What is methamphetamine?
Methamphetamine is a stimulant drug usually used as a white, bitter-tasting powder or a pill. Crystal methamphetamine is a form of the drug that looks like glass fragments or shiny, bluish-white rocks. It is chemically similar to amphetamine [a drug used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy, a sleep disorder]. Other common names for methamphetamine include chalk, crank, crystal, ice, meth, and speed.

How do people use methamphetamine?
People can take methamphetamine by:

• inhaling/smoking
• swallowing (pill)
• snorting
• injecting the powder that has been dissolved in water/alcohol

Because the “high” from the drug both starts and fades quickly, people often take repeated doses in a “binge and crash” pattern. In some cases, people take methamphetamine in a form of binging known as a “run,” giving up food and sleep while continuing to take the drug every few hours for up to several days.

How does methamphetamine affect the brain?
Methamphetamine increases the amount of the natural chemical dopamine in the brain. Dopamine is involved in body movement, motivation, and reinforcement of rewarding behaviors. The drug’s ability to rapidly release high levels of dopamine in reward areas of the brain strongly reinforces drug-taking behavior, making the user want to repeat the experience.

Short-Term Effects
Taking even small amounts of methamphetamine can result in many of the same health effects as those of other stimulants, such as cocaine or amphetamines. These include:

• increased wakefulness and physical activity
• decreased appetite
• faster breathing
• rapid and/or irregular heartbeat
• increased blood pressure and body temperature

How Do Manufacturers Make Methamphetamine?
Manufacturers make most of the methamphetamine found in the United States in “superlabs” here or, more often, in Mexico. But some also make the drug in small, secret labs with inexpensive over-the-counter ingredients such as pseudoephedrine, a common ingredient in cold medicines. To curb production, the law requires pharmacies and other retail stores to keep a purchase record of products containing pseudoephedrine. A person may only buy a limited amount of those products on a single day.

What are other health effects of methamphetamine?

Long-Term Effects

People who inject methamphetamine are at increased risk of contracting infectious diseases such as HIV and hepatitis B and C. These diseases are transmitted through contact with blood or other bodily fluids. Methamphetamine use can also alter judgment and decision-making leading to risky behaviors, such as unprotected sex, which also increases risk for infection.

Methamphetamine use may worsen the progression of HIV/AIDS and its consequences. Studies indicate that HIV causes more injury to nerve cells and more cognitive problems in people who have HIV and use methamphetamine than it does in people who have HIV and don’t use the drug.¹ Cognitive problems are those involved with thinking, understanding, learning, and remembering.

Long-term methamphetamine use has many other negative consequences, including:

• extreme weight loss
• severe dental problems (“meth mouth”)
• intense itching, leading to skin sores from scratching
• anxiety
• confusion
• sleeping problems
• violent behavior
• paranoia—extreme and unreasonable distrust of others
• hallucinations—sensations and images that seem real though they aren’t

In addition, continued methamphetamine use causes changes in the brain’s dopamine system that are associated with reduced coordination and impaired verbal learning. In studies of people who used methamphetamine over the long term, severe changes also affected areas of the brain involved with emotion and memory.² This may explain many of the emotional and cognitive problems observed in those who use methamphetamine.

Although some of these brain changes may reverse after being off the drug for a year or more, other changes may not recover even after a long period of abstinence.³ A recent study even suggests that people who used methamphetamine have an increased the risk of developing Parkinson’s disease, a disorder of the nerves that affects movement.⁴